December 4, 2025- The American Cancer Society (ACS) released updated guidelines for cervical cancer screening, reflecting advances in disease detection and accessibility in the United States. The updated guideline for women at average risk and individuals with a cervix at average risk introduces two key changes: self-collection of vaginal samples for Human papillomavirus (HPV) testing as an option for cervical cancer screening, and provides new guidance on when individuals can safely exit screening for the disease. The update is published in a report in CA: A Cancer Journal for Clinicians, the flagship journal of ACS.