December 12, 2025- For years, hospitals have evaluated artificial intelligence (AI) in healthcare the same way they evaluate most capital investments: through the narrow lens of financial return, according to Premier. Savings, cost reduction, revenue lift, throughput gains and similar metrics tend to dominate nearly every AI business case placed in front of a CFO.
But the traditional return on investment (ROI) paradigm is fundamentally flawed. A growing body of literature, validated by real-world performance across dozens of health systems, shows that clinical impact — not just cost savings — should be a significant driver behind the evaluations of AI solutions in healthcare.
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